Week Ten of the NFL season contained seven quarterbacks who passed for 300 yards or more and seven running backs who rushed for 100 yards or more.

The seven quarterbacks who passed for 300 yards or more and the WON/LOSS result of their teams in Week Ten is as follows:

Ryan, Atlanta  351  LOSS
Brady, New England  329  WIN
Stafford, Detroit  329  LOSS
Brees, New Orleans  322  WIN
Skelton, Arizona  315  WIN
Manning, NYGiants  311 LOSS
Sanchez, NYJets  306  LOSS

That works out to a WON/LOSS record of 3 WINS/4 LOSS, or a 43% winning percentage.

The seven running backs who rushed for 100 yards or more and the WON/LOSS result of their teams in Week Ten is as follows:

Bush, Oakland  157  WIN
Murray, Dallas  135  WIN
Johnson, Tennessee  130  WIN
Jackson, St. Louis  128  WIN
Jackson, Buffalo  114  LOSS
Jones-Drew, Jacksonville  114  WIN
Lynch, Seattle  109  WIN

That works out to a WON/LOSS record of 6 WINS/1 LOSS, or an 86% winning percentage.
Year-to-date, this is how these statistics break down:

500 YARD PASSERS
1 WIN/0 LOSSES  100% Winning Percentage

400 YARD PASSERS
3 WINS/7 LOSSES 30% Winning Percentage

300 YARD PASSERS
42 WINS/37 LOSSES  53% Winning Percentage

200 YARD RUSHERS
2 WINS/0 LOSSES  100% winning percentage

100 YARD RUSHERS
59 WINS/16 LOSSES  79% Winning Percentage

TWO 100 YARD RUSHERS ON THE SAME TEAM
3 WIN/0 LOSSES  100% Winning Percentage

BOTH A 300 YARD PASSER AND 100 YARD RUSHERS
3 WIN/1 LOSS  75% Winning Percentage

Currently for the season, teams who have had quarterbacks pass for 300 yards or more would have a won/loss record total in a 16-game season of 8 WINS/8 LOSSES.

Currently for the season, teams who have had player rush for 100 yards or more would have a WON/LOSS record total in a 16-game season of 13 WINS/3 LOSSES.
The bottom line in the NFL is winning games.To this point in the season, it appears the best chance to win in the NFL is to have a player rush for 100 yards or more during each game.